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Wednesday, April 16, 2014

Accidental Discoveries

Nobel prize-winning biochemist Albert Szent-Györgyi said, “A discovery is said to be an accident meeting a prepared mind.”
There are many items that we use today without thinking about how they were created.  I’d like to share a few things with which we are all familiar that were discovered or created by accident.  I acquired this information from a variety of websites.  I hope you find this as interesting as I did.
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Silly Putty - In the early 1940s, General Electric scientist James Wright was working on artificial rubber for the war effort when he mixed boric acid and silicon oil. V-J Day didn't come any sooner, but comic strip image-stretching practically became a national pastime.
Potato Chips - Chef George Crum concocted the perfect sandwich complement in 1853 when a customer who complained his fries were cut too thick, he sliced a potato paper-thin and fried it to a crisp. Needless to say, the diner couldn't eat just one.
Penicillin - Forever enshrined in scientific legend, the discovery of penicillin—a group of antibiotics used to combat a variety of bacterial infections—is a case of dirty dishes. Scottish biologist Alexander Fleming took a vacation from his lab where he was investigating staphylococci, known commonly as staph. Upon his return, he noticed a strange fungus on a culture he had left in his lab—a fungus that had killed off all surrounding bacteria in the culture. Modern medicine was never the same.

Velcro - On a hiking trip in 1941, Swiss engineer Georges de Mestral found burrs clinging to his pants and to his dog's fur. On closer inspection, he found that the burr's hooks would cling to anything loop-shaped. What if he could artificially re-create the loops?  The result: Velcro.  In the 1960’s, NASA was a notable client. The agency used the material in flight suits and to help secure items in zero gravity.  It then became a space-age fashion all its own.

Teflon - In 1938, Roy Plunkett, a scientist with DuPont, was working on ways to make refrigerators more home-friendly by searching for ways to replace the current refrigerant, which was primarily ammonia, sulfur dioxide, and propane. Upon opening the container on one sample, Plunkett found his experimental gas was gone. What remained was a strange, slippery resin that was resistant to extreme heat and chemicals. In the 1940s the material was used by the Manhattan project. A decade later it found its way into the automotive industry. It wasn't until the '60s that Teflon would be used for its most noted application: nonstick cookware.

Coca-Cola - The inventor of the Coca-Cola wasn't a shrewd businessman, a seller of sweets, or a dreamer looking to strike it rich in the beverage business. John Pemberton, a pharmacist, just wanted to cure headaches. Pemberton used two main ingredients in his hopeful headache cure: coca leaves and cola nuts. When his lab assistant accidentally mixed the two with carbonated water, the world's first Coke was the result. Over the years, Coke would tinker with the now-secret recipe. Pemberton died two years later and never saw his simple mixture create a soft drink empire.

Kellogg’s Corn Flakes - Who knew that one of America's first beloved cereals was invented by accident?  Will Keith Kellogg assisted his brother, a doctor at the Battle Creek Sanitarium in Michigan, with patients and their diets.
Responsible for making bread dough one day, he accidentally left his main ingredient - boiled wheat - sitting out for several hours. When he came back to roll the ingredient into dough, the wheat became flaky.
Curious, Kellogg baked the flaky dough anyway, creating a crunchy and flaky snack. The flakes were a hit with patients, so Kellogg tinkered with his recipe and finally settled on using corn as a main ingredient for the flakes. He launched “The Battle Creek Toasted Corn Flakes Company,” in 1906, which eventually was renamed the Kellogg's company.
Pacemakers - An assistant professor at the University of Buffalo thought he had ruined his project. Instead of picking a 10,000-ohm resistor out of a box to use on a heart-recording prototype, Wilson Greatbatch took the 1-megaohm variety. The resulting circuit produced a signal that sounded for 1.8 milliseconds, and then paused for a second — a dead ringer for the human heart. Greatbatch realized the precise current could regulate a pulse, overriding the imperfect heartbeat of the ill. Previously pacemakers were television-sized, cumbersome things that were temporarily attached to patients from the outside. But now the effect could be achieved with a small circuit, perfect to tuck into someone's chest.PACEMAKER
Wilson Greatbatch expressed an insatiable interest in circuitry and held revolutionary thoughts about how to fix naturally occurring problems in the human body.
Greatbatch was on the hunt for a solution for 'heart block,' a condition in which a heart does not receive messages from surrounding nerves to pump blood correctly. In contrast to other scientists who used large and cumbersome gadgets to stimulate heart muscle, Greatbatch wanted to devise a smaller implant to get the job done.
Though Greatbatch intended to create a machine to mend a broken heart, his moment of discovery may surprise you. While building an oscillator to record heart beat sounds in animals at Cornell University in 1958, he accidentally grabbed the wrong transistor and installed it in his device. Realizing his mistake, Greatbatch was still curious to see what would happen. Not expecting the oscillator to work, he switched it on and heard a familiar, rhythmic pulsing sound -- a pattern remarkably similar to a heart.
By chance, his invention, known as the pacemaker, was ideal for pulsating signals to the heart. He tested his new creation on animals and fine-tuned the device before implanting it into a human in 1960. In recent years, Greatbatch has been lauded for his achievement -- even if he discovered his solution by chance.

Anesthesia - Without this discovery, medical treatments would be a big pain - literally.  Although the true discoverer of anesthesia is contested, the people who contributed to its development and use were inspired by similar accidental observations.  Crawford Long, William Morton, Charles Jackson and Horace Wells all were associated with the creation of anesthesia. They realized that in some cases, ether and nitrous oxide (laughing gas) inhibited pain in people under their influence.  In the 1800s, anesthesia's founding fathers learned how this combination affected people's perceptions of pain.
In 1844, Horace Wells attended an exhibit and witnessed a participant injure his leg while under the influence of laughing gas. The man, whose leg was bleeding, told Wells that he didn't feel any pain.  After his accidental discovery, he used the compound while he removed his tooth. From there, anesthesia's use during medical, dental and surgical procedures took off.
The Post-it-Note - CORN FLAKES
Who knew that one of America's first beloved cereals was invented by accident?
It all started with Will Keith Kellogg, his interest in medicine and a bout of forgetfulness. Kellogg assisted his brother, who worked as a doctor at the Battle Creek Sanitarium in Michigan, with patients and their diets.
While conducting research with his brother and helping cook meals for patients, Kellogg stumbled upon a discovery that would change his life.
Responsible for making bread dough one day, Kellogg accidentally left his main ingredient -- boiled wheat -- sitting out for several hours. When he came back to roll the ingredient into dough, the wheat became flaky. Curious to see what would happen, Kellogg baked the flaky dough anyway, creating a crunchy and flaky snack. The flakes were a hit with patients, so Kellogg embarked on a mission to enhance the product for large-scale sale.
Will Kellogg tinkered with his recipe and finally settled on using corn as a main ingredient for the flakes. He launched his business, 'The Battle Creek Toasted Corn Flakes Company,' in 1906, which eventually came to be known as the Kellogg's company that sells Corn Flakes, other cereals and convenience foods today.
Its inventor, Art Fry, a now-retired 3M scientist while trying to create a strong adhesive, instead ended up as an adhesive that could be temporarily stuck to paper and other materials.  Fry and others fiddled with the idea for several years before the product went into full production in 1980.
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